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Deaf children in China can hear after gene therapy

  • The trial used gene therapy to try to treat a form of profound deafness
  • Four of the five children gained the ability to hear after treatment
  • A harmless virus was implanted containing a new genetic code

CHENGDU, CHINA – NOVEMBER 7: (CHINA OUT) A teacher helps a hearing handicapped child to wear hearing aid at the Chengdu Special Education School on November 7, 2005 in Chengdu of Sichuan Province, China. Chengdu Special Education School, established in 1922, was built to provide education for vision and hearing handicapped children and youth. The school currently has 333 students, 90 teachers and service personnel. It has gradually developed into a comprehensive special education school, opening classes of preschool, primary and secondary education. According to state media, China has over 1.4 million handicapped children under six-years-old, and the figure is rising by approximately 200,000 a year. (Photo by China Photos/Getty Images)

 

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(NewsNation) — A gene therapy trial has allowed some children in China who were born entirely deaf to hear for the first time.

Reported in the journal Science, researchers from Fudan University fitted the children’s inner ears with an implant that contained a harmless virus carrying a new genetic code.

According to the researchers, four of the five children could hear after the treatment.

All of the children were born deaf due to inheriting two defective copies of a gene. This gene controls how the body makes a protein that gives hair cells in the inner ear the ability to transmit sounds to the brain.

At least one of the children in the trial had previously had a cochlear implant that allowed her to hear and learn to speak but could hear naturally after the trial. While cochlear implants can enable some deaf people to hear, they don’t allow for the same spectrum of sound as natural hearing and come with other side effects and limitations.

That particular form of deafness is rare and is only responsible for one to three percent of cases of deaf children.

Children born with hearing loss may face barriers when developing communication skills and miss important developmental milestones if they aren’t provided with support from the start.

The trial is not the only effort to use gene therapy to treat deafness. Another trial in Cambridge is also attempting to find a solution to deafness related to the same gene.

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